Sepsis: frontiers in supportive care, organisation and research.

Anders Perner, Andrew Rhodes, Bala Venkatesh, Derek C Angus, Ignacio Martin-Loeches, Jean-Charles Preiser, Jean-Louis Vincent, John Marshall, Konrad Reinhart, Michael Joannidis, Steven M Opal

Journal: Intensive care medicine 2017;43(4):496-508

PMID: 28130686

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Abstract

Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short- and long-term morbidity, mortality and costs remain high in both developed and developing countries. Thus, further improvements in supportive interventions and organisation of care are likely to have a substantial impact upon global health. In this narrative review, invited experts describe the challenges and progress to be made in sepsis research and care in the near future. We focus on supportive care (pulmonary, endocrine, renal, and nutritional support, mediator modulation and precision medicine), organisational themes (guidelines, outcome measures and stakeholder involvement) and clinical research as key areas to improving the care and outcomes of patients with sepsis.

Address: Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. [email protected].; St. George's Healthcare NHS Trust, St George's University of London, London, UK.; Department of Intensive Care, Wesley Hospital and Princess Alexandra Hospital, University of Queensland, St Lucia, Australia.; University of Sydney, Sydney, Australia.; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA.; Multidisciplinary Intensive Care Research Organization (MICRO), Wellcome Trust-HRB Clinical Research, Dublin, Ireland.; Department of Clinical Medicine, Trinity Centre for Health Sciences, St James's University Hospital, Dublin, Ireland.; CIBER enfermedades respiratorias (CIBERES), Critical Care Center, Madrid, Spain.; Department of Intensive Care, Erasme University Hospital, Université libre de Bruxelles, Brussels, Belgium.; Departments of Surgery and Critical Care Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.; Jena University Hospital, Jena, Germany.; Division of Intensive Care and Emergency Medicine, Medical University Innsbruck, Innsbruck, Austria.; Infectious Diseases Division, The Alpert Medical School of Brown University, Providence, RI, USA.

DOI: 10.1007/s00134-017-4677-4

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https://dx.doi.org/10.1007/s00134-017-4677-4

MeSH Terms: Biomedical Research, Cost of Illness, Global Burden of Disease, Guidelines as Topic, Health Services Administration, Humans, Incidence, Outcome and Process Assessment, Health Care, Precision Medicine, Sepsis