Sketching of CD95 Oligomers by In Silico Investigations.

Nicolas Levoin

Journal: Methods in molecular biology (Clifton, N.J.) 2018;1557():153-171

PMID: 28078591

Abstract

This work aimed at building a 3D model of trimeric apo CD95. By combining different molecular modeling approaches and experimental information, we have been able to obtain a consensual organization of the complex. Our strategy permitted the construction of a plausible trimer, and to sketch the interface between protomers. The final model will guide further experimental investigations and understanding of CD95 structure and functions.

Address: Bioprojet-Biotech, 4 rue du Chesnay Beauregard, 5762, Saint Gregoire, France. [email protected].

DOI: 10.1007/978-1-4939-6780-3_15

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https://assays.cancer.gov/CPTAC-369

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https://antibodies.cancer.gov/detail/CPTC-FAS-1

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https://doi.org/10.1007/978-1-4939-6780-3_15

MeSH Terms: Amino Acid Sequence, Computer Simulation, Databases, Protein, Humans, Models, Molecular, Molecular Dynamics Simulation, Protein Conformation, Protein Multimerization, Software, Web Browser, fas Receptor