The use of amino acid PET and conventional MRI for monitoring of brain tumor therapy.

Norbert Galldiks, Ian Law, Whitney B Pope, Javier Arbizu, Karl-Josef Langen

Journal: NeuroImage. Clinical 2017;13():386-394

PMID: 28116231

Abstract

Routine diagnostics and treatment monitoring of brain tumors is usually based on contrast-enhanced MRI. However, the capacity of conventional MRI to differentiate tumor tissue from posttherapeutic effects following neurosurgical resection, chemoradiation, alkylating chemotherapy, radiosurgery, and/or immunotherapy may be limited. Metabolic imaging using PET can provide relevant additional information on tumor metabolism, which allows for more accurate diagnostics especially in clinically equivocal situations. This review article focuses predominantly on the amino acid PET tracers C-methyl-l-methionine (MET), -(2-[F]fluoroethyl)-l-tyrosine (FET) and 3,4-dihydroxy-6-[F]-fluoro-l-phenylalanine (FDOPA) and summarizes investigations regarding monitoring of brain tumor therapy.

Address: Dept. of Neurology, University of Cologne, Cologne, Germany; Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Jülich, Germany; Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany.; Dept.of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Dept. of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.; Dept. of Nuclear Medicine, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.; Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Jülich, Germany; Dept. of Nuclear Medicine, University of Aachen, Aachen, Germany.
Bant logo

© Copyright 2026, Nutrition Evidence

NED wishes to thank the following organisations for their support:

We use cookies to improve your experience and analyze site traffic with Google Analytics. By continuing to use our site, you agree to our use of cookies. Learn more.