Fizza Arain, Lars Gullestad, Ståle Nymo, John Kjekshus, John G Cleland, Annika Michelsen, John J McMurray, John Wikstrand, Pål Aukrust, Thor Ueland
Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017;22(3-4):261-267
PMID: 27325138
CONTEXT AND OBJECTIVE
To evaluate if YKL-40 can provide prognostic information in patients with ischemic heart failure (HF) and identify patients who may benefit from statin therapy.
MATERIALS AND METHODS
The association between serum YKL-40 and predefined outcome was evaluated in 1344 HF patients assigned to rosuvastatin or placebo.
RESULTS
YKL-40 was not associated with outcome in adjusted analysis. In YKL-40 tertile 1, an effect on the primary outcome (HR 0.50, p = 0.006) and CV death (HR 0.54, p = 0.040) was seen by rosuvastatin in adjusted analysis.
CONCLUSIONS
A beneficial modification of outcome was observed with statin therapy in patients with low YKL-40 levels.
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