Low YKL-40 in chronic heart failure may predict beneficial effects of statins: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA).

Fizza Arain, Lars Gullestad, Ståle Nymo, John Kjekshus, John G Cleland, Annika Michelsen, John J McMurray, John Wikstrand, Pål Aukrust, Thor Ueland

Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2017;22(3-4):261-267

PMID: 27325138

Abstract

CONTEXT AND OBJECTIVE

To evaluate if YKL-40 can provide prognostic information in patients with ischemic heart failure (HF) and identify patients who may benefit from statin therapy.

MATERIALS AND METHODS

The association between serum YKL-40 and predefined outcome was evaluated in 1344 HF patients assigned to rosuvastatin or placebo.

RESULTS

YKL-40 was not associated with outcome in adjusted analysis. In YKL-40 tertile 1, an effect on the primary outcome (HR 0.50, p = 0.006) and CV death (HR 0.54, p = 0.040) was seen by rosuvastatin in adjusted analysis.

CONCLUSIONS

A beneficial modification of outcome was observed with statin therapy in patients with low YKL-40 levels.

Address: a Department of Cardiology , Oslo University Hospital Rikshospitalet , Oslo , Norway.; b Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.; c K.G. Jebsen Cardiac Research Centre and Center for Heart Failure Research , University of Oslo , Oslo , Norway.; d Faculty of Medicine , University of Oslo , Oslo , Norway.; e Department of Cardiology , Hull York Medical School, University of Hull, Castle Hill Hospital , Kingston-upon-Hull, Glasgow , UK.; f British Heart Foundation Glasgow Cardiovascular Research Centre , University of Glasgow , Glasgow , UK.; g Sahlgrenska University Hospital , Gøteborg , Sweden.; h K.G. Jebsen Inflammatory Research Center , University of Oslo , Oslo , Norway.; i Section of Clinical Immunology and Infectious Diseases , Oslo University Hospital Rikshospitalet Oslo , Norway.; j K.G. Jebsen Thrombosis Research and Expertise Center , University of Tromsø , Tromsø , Norway.
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