Chemopreventive effect of natural dietary compounds on xenobiotic-induced toxicity.

Jia-Ching Wu, Ching-Shu Lai, Mei-Ling Tsai, Chi-Tang Ho, Ying-Jan Wang, Min-Hsiung Pan

Journal: Journal of food and drug analysis 2017;25(1):176-186

PMID: 28911535

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Abstract

Contaminants (or pollutants) that affect human health have become an important issue, spawning a myriad of studies on how to prevent harmful contaminant-induced effects. Recently, a variety of biological functions of natural dietary compounds derived from consumed foods and plants have been demonstrated in a number of studies. Natural dietary compounds exhibited several beneficial effects for the prevention of disease and the inhibition of chemically-induced carcinogenesis. Contaminant-induced toxicity and carcinogenesis are mostly attributed to the mutagenic activity of reactive metabolites and the disruption of normal biological functions. Therefore, the metabolic regulation of hazardous chemicals is key to reducing contaminant-induced adverse health effects. Moreover, promoting contaminant excretion from the body through Phase I and II metabolizing enzymes is also a useful strategy for reducing contaminant-induced toxicity. This review focuses on summarizing the natural dietary compounds derived from common dietary foods and plants and their possible mechanisms of action in the prevention/suppression of contaminant-induced toxicity.

Address: Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.; Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung, Taiwan.; Department of Food Science, Rutgers University, New Brunswick, NJ, USA.; Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.; Department of Biomedical Informatics, Asia University, Taichung, Taiwan.; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.; Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan.

DOI: 10.1016/j.jfda.2016.10.019

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MeSH Terms: Anticarcinogenic Agents, Diet, Humans, Xenobiotics