Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets.

Michitaka Suzuki

Journal: Anatomical science international 2017;92(1):50-54

PMID: 27822589

Abstract

Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids to regulate cellular lipid homeostasis. Fatty acids are packaged as triglyceride and cholesterol ester into endoplasmic reticulum (ER) membranes to synthesize LDs. Cytosolic LDs move dynamically and interact with organelles, including other LDs. In this process, functional proteins for metabolism are also transferred to LDs. In this review, I focus on interactions between the ER and LDs related to lipid metabolism.

Address: Department of Molecular Genetics and Microbiology, Duke University, 272 Jones Building Box 3580, DUMC, Durham, NC, 27710, USA. [email protected].

DOI: 10.1007/s12565-016-0378-2

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https://dx.doi.org/10.1007/s12565-016-0378-2

MeSH Terms: Endoplasmic Reticulum, Humans, Lipid Droplets, Lipid Metabolism, Lipolysis, Mitochondrial Membranes, Organelles, Perilipin-1, Perilipins, Phosphatidylcholines, Protein Binding, Proteolysis