Vancouver Experience of Recombinant Human Platelet-Derived Growth Factor.

Alistair Younger, Murray Penner, Harvey E Montijo

Journal: Foot and ankle clinics 2017;21(4):771-776

PMID: 27871410

Full Text on Elsevier Science View on PubMed

Abstract

Joint arthrodesis utilizing autogenous bone graft remains the gold standard of treatment in fusion procedures of the foot and ankle. Graft harvest, however, has been associated with increased morbidity to patients as well as increased costs. With this in mind, multiple clinical studies have evaluated the efficacy of recombinant human platelet-derived growth factor (rh-PDGF-BB) with beta-tricalcium phosphate (B-TCP) to augment in foot and ankle arthrodesis with favorable results. These factors have led to the increased use of rh-PDGF-BB with B-TCP in Vancouver with good clinical results.

Address: Department of Orthopedics, University of British Columbia, 560-1144 Burrard Street, Vancouver, British Columbia V6Z 2A5, Canada. Electronic address: [email protected].; Department of Orthopedics, University of British Columbia, 1000-1200 Burrard Street, Vancouver, British Columbia V6Z 2C7, Canada.; Department of Orthopedics, University of British Columbia, 560-1144 Burrard Street, Vancouver, British Columbia V6Z 2A5, Canada.

DOI: 10.1016/j.fcl.2016.07.009

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MeSH Terms: Ankle Joint, Arthrodesis, Becaplermin, Bone Transplantation, British Columbia, Calcium Phosphates, Foot, Fracture Healing, Fractures, Ununited, Humans, Proto-Oncogene Proteins c-sis, Randomized Controlled Trials as Topic