Beneficial Effects of Pterocarpan-High Soybean Leaf Extract on Metabolic Syndrome in Overweight and Obese Korean Subjects: Randomized Controlled Trial.

Ri Ryu, Tae-Sook Jeong, Ye Jin Kim, Ji-Young Choi, Su-Jung Cho, Eun-Young Kwon, Un Ju Jung, Hyeon-Seon Ji, Dong-Ha Shin, Myung-Sook Choi

Journal: Nutrients 2017;8(11):734

PMID: 27869712

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Abstract

Pterocarpans are known to have antifungal and anti-inflammatory properties. However, little is known about the changes in transcriptional profiles in response to a pterocarpan-high soybean leaf extract (PT). Therefore, this study investigated the effects of PT on blood glucose and lipid levels, as well as on the inflammation-related gene expression based on a peripheral blood mononuclear cells (PBMCs) mRNA sequencing analysis in Korean overweight and obese subjects with mild metabolic syndrome. The participants were randomly assigned to two groups and were administered either placebo (starch, 3 g/day) or PT (2 g/day) for 12 weeks. The PT intervention did not change body weight, body fat percentage and body mass index (BMI). However, PT significantly decreased the glycosylated hemoglobin (HbA1c), plasma glucose, free fatty acid, total cholesterol, and non-HDL cholesterol levels after 12 weeks. Furthermore, PT supplementation significantly lowered the homeostatic index of insulin resistance, as well as the plasma levels of inflammatory markers. Finally, the mRNA sequencing analysis revealed that PT downregulated genes related to immune responses. PT supplementation is beneficial for the improvement of metabolic syndrome by altering the fasting blood and plasma glucose, HbA1c, plasma lipid levels and inflammation-related gene expression in PBMCs.

Address: Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. [email protected].; Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea. [email protected].; Industrial Bio-Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea. [email protected].; Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. [email protected].; Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea. [email protected].; Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea. [email protected].; Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea. [email protected].; Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea. [email protected].; Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Korea. [email protected].; Industrial Bio-Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea. [email protected].; College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea. [email protected].; Insect Biotech Co., Ltd., Daejeon 305-811, Korea. [email protected].; Department of Food Science and Nutrition, Kyungpook National University, 80 Daehakro, Bukgu, Daegu 41566, Korea. [email protected].; Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, Korea. [email protected].

DOI: 10.3390/nu8110734

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https://data.niaid.nih.gov/resources?id=gse80714

MeSH Terms: Adult, Aged, Biomarkers, Blood Glucose, Double-Blind Method, Female, Gene Expression Regulation, Glycated Hemoglobin, Humans, Inflammation Mediators, Insulin Resistance, Leukocytes, Mononuclear, Lipids, Male, Metabolic Syndrome, Middle Aged, Overweight, Phytotherapy, Plant Extracts, Plant Leaves, Plants, Medicinal, Pterocarpans, Republic of Korea, Signal Transduction, Glycine max, Time Factors, Treatment Outcome