Orosomucoid as prognosis factor associated with inflammation in acute or nutritional status in chronic heart failure.

Rosa M Agra, Alfonso Varela-Román, Rocío González-Ferreiro, Juan E Viñuela, Ana Castro-Pais, Ángel Fernández-Trasancos, Esther Díaz-Rodríguez, Ezequiel Álvarez, Marcos C Carreira, Felipe F Casanueva, José R González-Juanatey, Sonia Eiras

Journal: International journal of cardiology 2017;228():488-494

PMID: 27875723

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Inflammation and nutritional state are involved in the pathogenesis of heart failure (HF).

OBJECTIVE

To study the contribution of alpha-1-acid-glycoprotein (AGP) to these factors and its prognostic value in acute (AHF) or chronic HF (CHF).

METHODS

The observational study has included 147 patients (mean age 70years, 62% men) admitted to a cardiology department for HF and followed-up for an average 326.6±140.8days. Blood AGP values were measured by Enzyme-Linked ImmunoSorbent Assay. Monocytes subsets were determined with CD14 and CD16 antibodies by flow cytometry and body composition was measured by dual-energy X-ray absorptiometry. The regulation of tumor necrosis factor (TNF-α) and leptin by AGP in epicardial adipose tissue (EAT) were analyzed by real time polymerase chain reaction.

RESULTS

High AGP, that was associated with CD14CD16 monocytes, and proBNP levels at the discharge were indicators of rehospitalization for HF in AHF patients. However, low AGP levels determined a worse nutritional state in CHF patients. The leptin levels were downregulated by high AGP concentration in epicardial fat.

CONCLUSION

AGP is a dual indicator in HF because high levels are predictors of adverse outcomes in AHF but low levels are related to the worse nutritional status in CHF. The regulation of leptin by AGP in epicardial fat might suggest a new pathway as protective mechanism in CHF.

Address: Cardiovascular Area and Coronary Unit, Complejo Hospitalario Universitario de Santiago de Compostela, Spain; Cardiology Group, Health Research Institute of Santiago de Compostela, Spain.; Cardiovascular Area and Coronary Unit, Complejo Hospitalario Universitario de Santiago de Compostela, Spain.; Immunology Unit, Complejo Hospitalario Universitario de Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.; Cardiology Group, Health Research Institute of Santiago de Compostela, Spain.; CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Laboratory of Molecular and Cellular Endocrinology, Department of Medicine, Endocrinology Division, University of Santiago de Compostela and Complejo Hospitalario Universitario, Santiago de Compostela, Spain.; Cardiology Group, Health Research Institute of Santiago de Compostela, Spain. Electronic address: [email protected].

DOI: 10.1016/j.ijcard.2016.11.134

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MeSH Terms: Absorptiometry, Photon, Aged, Biomarkers, Body Composition, Enzyme-Linked Immunosorbent Assay, Female, Heart Failure, Humans, Inflammation, Male, Monocytes, Nutritional Status, Orosomucoid, Prognosis, Retrospective Studies