ATIC missense variant affects response to methotrexate treatment in rheumatoid arthritis patients.

Mateusz Kurzawski, Damian Malinowski, Natalia Szarmach, Anna Nowak, Aleksandra Goryniak, Andrzej Pawlik, Marek Droździk

Journal: Pharmacogenomics 2017;17(18):1971-1978

PMID: 27885916

Abstract

AIM

The study was aimed at investigation of several gene variants of folate pathway enzymes for their potential association with methotrexate (MTX) treatment response in patients with rheumatoid arthritis.

PATIENTS & METHODS

Four hundred and twenty two Caucasian patients were classified as good or poor responders, and subsequently genotyped for common SNPs in DHFR, FPGS and ATIC genes.

RESULTS

No significant differences were observed in case of DHFR and FGPS SNPs. As for ATIC rs2372536 (Thr116Ser), GG minor genotype was significantly associated with good response to MTX (OR: 2.40; 95% CI: 1.30-4.42; p = 0.005), which was confirmed by multivariate analysis.

CONCLUSION

The results of the study suggest that ATIC missense rs2372536 SNP may influence response to MTX therapy in rheumatoid arthritis patients.

Address: Department of Experimental & Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.; Department of Physiology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.

DOI: 10.2217/pgs-2016-0125

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MeSH Terms: Adult, Aged, Arthritis, Rheumatoid, Female, Humans, Hydroxymethyl and Formyl Transferases, Male, Methotrexate, Middle Aged, Multienzyme Complexes, Nucleotide Deaminases, Polymorphism, Single Nucleotide, Tetrahydrofolate Dehydrogenase