Chili pepper as a body weight-loss food.

Sharon Varghese, Peter Kubatka, Luis Rodrigo, Katarina Gazdikova, Martin Caprnda, Julia Fedotova, Anthony Zulli, Peter Kruzliak, Dietrich Büsselberg

Journal: International journal of food sciences and nutrition 2017;68(4):392-401

PMID: 27899046

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Abstract

Chili has culinary as well as medical importance. Studies in humans, using a wide range of doses of chili intake (varying from a single meal to a continuous uptake for up to 12 weeks), concluded that it facilitates weight loss. In regard to this, the main targets of chili are fat metabolism, energy expenditure, and thermogenesis. To induce weight loss, the active substance of chili, capsaicin, activates Transient Receptor Potential Cation Channel sub-family V member 1 (TRPV1) channels) receptors causing an increase in intracellular calcium levels and triggering the sympathetic nervous system. Apart from TRPV1, chili directly reduces energy expenditure by activating Brown Adipose Tissue. Weight loss by chili is also the result of an improved control of insulin, which supports weight management and has positive effects for treatment for diseases like obesity, diabetes and cardiovascular disorders. This review summarizes the major pathways by which chili contributes to ameliorating parameters that help weight management and how the consumption of chili can help in accelerating weight loss through dietary modifications.

Address: a Weill Cornell Medicine in Qatar , Qatar Foundation-Education City , Doha , Qatar.; b Department of Medical Biology, Jessenius Faculty of Medicine , Comenius University in Bratislava , Martin , Slovakia.; c Department of Gastroenterology, Faculty of Medicine , University of Oviedo, Central University Hospital of Asturias (HUCA) , Oviedo , Spain.; d Department of Nutrition, Faculty of Nursing and Professional Health Studies, Faculty of Medicine , Slovak Medical University , Bratislava , Slovakia.; e Department of General Medicine, Faculty of Medicine , Slovak Medical University , Bratislava , Slovakia.; f 2nd Department of Internal Medicine, Faculty of Medicine , Comenius University and University Hospital , Bratislava , Slovakia.; g Laboratory of Neuroendocrinology , I.P. Pavlov Institute of Physiology, Russian Academy of Sciences , St. Petersburg , Russia.; h Laboratory of Comparative Somnology and Neuroendocrinology , I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences , St. Petersburg , Russia.; i International Research Centre «Biotechnologies of the Third Millennium» , ITMO University , St. Petersburg , Russia.; j Centre for Chronic Disease, College of Health and Biomedicine , Victoria University , Werribee , Australia.; k Department of Chemical Drugs, Faculty of Pharmacy , University of Veterinary and Pharmaceutical Sciences , Brno , Czech Republic.; l Department of Surgery, Center for Vascular Disease , St. Anne?s University Hospital, Faculty of Medicine, Masaryk University , Brno , Czech Republic.

DOI: 10.1080/09637486.2016.1258044

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MeSH Terms: Capsaicin, Capsicum, Humans, Lipid Metabolism, Weight Loss