Paraneoplastic pityriasis rubra pilaris: case report and literature review.

E Bar-Ilan, A Gat, E Sprecher, T Zeeli

Journal: Clinical and experimental dermatology 2018;42(1):54-57

PMID: 27896859

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Abstract

Pityriasis rubra pilaris (PRP; MIM 173200) is an uncommon papulosquamous inflammatory dermatosis. Only a few cases of PRP associated with an underlying malignancy have been documented. We investigated a 59-year-old patient presenting with a fulminant form of PRP recalcitrant to systemic retinoid therapy, in whom the skin disease heralded a diagnosis of cholangiocarcinoma. We searched the MEDLINE database to find articles reporting on similar associations of PRP with malignancies. We identified 10 studies linking PRP and malignancies, but an association between PRP and cholangiocarcinoma has not yet been reported.

Address: Department of Dermatology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.; Institute of Pathology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel.

DOI: 10.1111/ced.13009

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MeSH Terms: Bile Duct Neoplasms, Cholangiocarcinoma, Diagnosis, Differential, Female, Humans, Image-Guided Biopsy, Middle Aged, Paraneoplastic Syndromes, Pityriasis Rubra Pilaris, Positron-Emission Tomography, Skin