Low, but not high, dose caffeine is a readily available probe for adenosine actions.

Bertil B Fredholm, Jiangning Yang, Yingqing Wang

Journal: Molecular aspects of medicine 2018;55():20-25

PMID: 27915051

Full Text on Elsevier Science View on PubMed

Abstract

Caffeine is very widely used and knowledge of its mode of action can be used to gain an understanding of basal physiological regulation. This review makes the point that caffeine is - in low doses - an antagonist of adenosine acting at A, A and A receptors. We use published and unpublished data to make the point that high dose effects of caffeine are not only qualitatively different but have a different underlying mechanism. Therefore one must be careful in only using epidemiological or experimental data where rather low doses of caffeine are used to draw conclusions about the physiology and pathophysiology of adenosine.

Address: Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden. Electronic address: [email protected].; Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden; Division of Cardiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77, Stockholm, Sweden; Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

DOI: 10.1016/j.mam.2016.11.011

Link outs

Free resources

Medical:

https://medlineplus.gov/caffeine.html

Other Literature Sources:

https://scite.ai/reports/27915051

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0098...

MeSH Terms: Adenosine, Caffeine, Dose-Response Relationship, Drug, Humans