A new model for the origins of chronic disease.

D J Barker

Journal: Medicine, health care, and philosophy 2001;4(1):31-5

PMID: 11315417

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Abstract

Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.

Address: MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, SO16 6YD, UK.

DOI: 10.1023/a:1009934412988

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MeSH Terms: Causality, Chronic Disease, Coronary Disease, Embryonic and Fetal Development, Female, Genetics, Medical, Humans, Life Expectancy, Male, Models, Biological, Nutritional Physiological Phenomena, Placental Insufficiency, Pregnancy