Genome-wide analysis identifies 12 loci influencing human reproductive behavior.

Address: Department of Sociology and Nuffield College, University of Oxford, Oxford, UK.; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.; Department of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.; Sociology of Consumption and Households, Wageningen University Research, Wageningen, the Netherlands.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; Laboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, the Netherlands.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center, Gentofte, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.; Department of Genetics, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.; Department of Natural Science, University of Haifa, Haifa, Israel.; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; Department of Genetics, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.; Departments of Systems and Computational Biology, of Pathology and of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA.; Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and of Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.; School of Public Health, Faculty of Medicine, Imperial College, London, UK.; Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Department of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.; Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy.; Population, Policy and Practice, UCL Institute of Child Health, London, UK.; Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventative Medicine, Queen Mary University of London, London, UK.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Institute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK.; Health Economics Research Centre, University of Oxford, Oxford, UK.; 23andMe, Inc., Mountain View, California, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Cardiovascular and Metabolic Conditions Section, Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.; Centre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.; Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Neurosciences, KU Leuven, Leuven, Belgium.; Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.; Translational Immunology Laboratory, VIB, Leuven, Belgium.; University of Lille, CNRS, Institut Pasteur of Lille, Lille, France.; Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, Queensland, Australia.; Center for Lifespan Psychology, Max Planck Institute for Human Development and Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany.; Minnesota Center for Twin and Family Research, Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Biological Psychology, VU University, Amsterdam, the Netherlands.; EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.; School of Social and Community Medicine, University of Bristol, Bristol, UK.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Complex Trait Genetics, VU University, Amsterdam, the Netherlands.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.; Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.; Institute of Genetics and Biophysics 'A. 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Chan School of Public Health, Boston, Massachusetts, USA.; Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria.; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.; King's British Heart Foundation Centre, King's College London, London, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; University of Lille, CNRS, Institut Pasteur of Lille, Lille, France.; Centre for Neurogenetics and Statistical Genomics, University of Queensland, Brisbane, Queensland, Australia.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Data Coordinating Center, New York State Psychiatric Institute, New York, New York, USA.; Department of Medicine, Institute for Aging Research and the Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.; Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Institute of Genetics and Biophysics 'A. Buzzati-Traverso', CNR, Naples, Italy.; IRCCS Neuromed, Pozzilli, Isernia, Italy.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.; Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.; Vasa Central Hospital, Vasa, Finland.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.; Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.; Division of Experimental Genetics, Sidra, Doha, Qatar.; Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany.; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.; School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.; Hunter Medical Research Institute, Newcastle, New South Wales, Australia.; Population, Policy and Practice, UCL Institute of Child Health, London, UK.; Centre for Population Health Research, Sansom Institute of Health Research and School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway.; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.; Department of Economics, Stockholm School of Economics, Stockholm, Sweden.; Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.; Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK.; Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK.; Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.; Health Monitoring Unit, National Institute for Health and Welfare, Helsinki, Finland.; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Istituto di Ricerca Genetica e Biomedica, CMR, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.; Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Strangeways Research Laboratory, University of Cambridge, Cambridge, UK.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.; UKK Institute for Health Promotion,Tampere, Finland.; Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.; Danish Aging Research Center and Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; MONICA/KORA Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.; Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.; Department of BESC, Epidemiology Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.; Research Unit for Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.; Department of Psychology, University of Edinburgh, Edinburgh, UK.; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.; EMGO+ Institute for Health and Care Research, Amsterdam, the Netherlands.; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Population, Policy and Practice, UCL Institute of Child Health, London, UK.; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.; Department of Health, National Institute for Health and Welfare, Helsinki, Finland.; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.; Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Departments of Epidemiology and Psychiatry, Columbia University Medical Center, New York, New York, USA.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig Maximilians Universität, Munich, Germany.; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Montpellier Business School, Montpellier, France.; Department of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; German Socio-Economic Panel Study (SOEP), Max Planck Institute for Human Development and Berlin University of Technology (TUB), Berlin, Germany.; Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK.; Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.; National Bureau of Economic Research, Cambridge, Massachusetts, USA.; Department of Economics, New York University, New York, New York, USA.; Research Institute for Industrial Economics, Stockholm, Sweden.; Department of Applied Economics, Erasmus School of Economics, Rotterdam, the Netherlands.; Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.; Complex Trait Genetics, VU University, Amsterdam, the Netherlands.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.