Breast cancer recurrence following radioguided seed localization and standard wire localization of nonpalpable invasive and in situ breast cancers: 5-Year follow-up from a randomized controlled trial.

Filgen Fung, Sylvie D Cornacchi, Michael Reedijk, Nicole Hodgson, Charlie H Goldsmith, David McCready, Gabriela Gohla, Colm Boylan, Peter J Lovrics

Journal: American journal of surgery 2017;213(4):798-804

PMID: 27810132

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery.

METHODS

Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM)). Univariate analysis was used.

RESULTS

Follow-up data were available for 298 patients (98%) and median follow-up time was 65 months. There were 11 (4%) cases of BC recurrence and median time to recurrence was 26 months. LR occurred in 8 patients (6 WL and 2 RSL; p = 0.28). Positive margins at first surgery (p = 0.024) and final surgery (p = 0.004) predicted for BC recurrence.

CONCLUSIONS

There was no detectable difference in BC recurrence between WL and RSL groups and positive margins at initial or final surgery both predicted for BC recurrence.

Address: Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada.; Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada.; Department of Surgical Oncology, Hamilton Health Sciences and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Arthritis Research Canada, Richmond, BC, Canada.; Department of Pathology, McMaster University, Hamilton, ON, Canada.; Department of Radiology, McMaster University, Hamilton, ON, Canada.; Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada. Electronic address: [email protected].

DOI: 10.1016/j.amjsurg.2016.06.016

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MeSH Terms: Breast Carcinoma In Situ, Breast Neoplasms, Carcinoma, Ductal, Breast, Female, Fiducial Markers, Follow-Up Studies, Humans, Iodine Radioisotopes, Mammography, Margins of Excision, Mastectomy, Segmental, Middle Aged, Neoplasm Recurrence, Local, Reoperation, Ultrasonography, Interventional