Going global by adapting local: A review of recent human adaptation.

Shaohua Fan, Matthew E B Hansen, Yancy Lo, Sarah A Tishkoff

Journal: Science (New York, N.Y.) 2017;354(6308):54-59

PMID: 27846491

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Abstract

The spread of modern humans across the globe has led to genetic adaptations to diverse local environments. Recent developments in genomic technologies, statistical analyses, and expanded sampled populations have led to improved identification and fine-mapping of genetic variants associated with adaptations to regional living conditions and dietary practices. Ongoing efforts in sequencing genomes of indigenous populations, accompanied by the growing availability of "-omics" and ancient DNA data, promises a new era in our understanding of recent human evolution and the origins of variable traits and disease risks.

Address: Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.; Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA. [email protected].; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

DOI: 10.1126/science.aaf5098

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MeSH Terms: Acclimatization, Adaptation, Physiological, Altitude, Dairy Products, Environment, Gene-Environment Interaction, Humans, Radiation Exposure, Rainforest, Selection, Genetic, Tropical Climate