Pancreas Preservation With Viaspan, Celsior, and Custodiol Solutions: An Initial Experience.

M C Montiel-Casado, J A Pérez-Daga, J A Blanco-Elena, J M Aranda-Narváez, B Sánchez-Pérez, M Cabello-Díaz, P Ruiz-Esteban, F J León-Díaz, C Gutiérrez-de la Fuente, J Santoyo-Santoyo

Journal: Transplantation proceedings 2017;48(9):3040-3042

PMID: 27932142

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

There is still controversy about which preservation solution in pancreas transplantation could be the best. The aim of this study was to analyze our initial experience with Custodiol solution (CuS) compared with Viaspan solution (VS) and Celsior solution (CS) in pancreas transplantation.

METHODS

A retrospective study included 94 consecutive pancreatic transplants, from 2007 until 2015. We compared 3 groups, depending on preservation solution: Viaspan (n = 41), Celsior (n = 40), or Custodiol (n = 13). The primary end point was patient and pancreas survival at 1 year after pancreas transplantation.

RESULTS

The recipient and donor characteristics were similar except in cold ischemia time; it was higher with Celsior. No differences were found in postoperative complications and pancreas graft function at 3 months, 6 months, and 1 year (glucose, HbA1c, C-peptide, creatinine). The pancreas and patient survival at 1 year was comparable (pancreas survival: VS, 80%; CS, 90%; CuS, 92%; log-rank, 0.875; and patient survival: VS, 92%; CS, 97%; CuS, 100%; log-rank, 0.9).

CONCLUSIONS

In our institution, the Custodiol solution in pancreas transplantation presented similar outcomes in terms of postoperative complications, pancreas graft function, and 1-year survival.

Address: Department of Digestive Surgery and Transplantation, Hospital Regional Universitario Carlos Haya, Málaga, Spain. Electronic address: [email protected].; Department of Digestive Surgery and Transplantation, Hospital Regional Universitario Carlos Haya, Málaga, Spain.; Department of Nephrology, Hospital Regional Universitario Carlos Haya, Málaga, Spain.

DOI: 10.1016/j.transproceed.2016.07.042

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MeSH Terms: Adenosine, Adult, Allopurinol, Blood Glucose, C-Peptide, Cold Ischemia, Disaccharides, Electrolytes, Female, Glucose, Glutamates, Glutathione, Graft Survival, Histidine, Humans, Insulin, Male, Mannitol, Organ Preservation, Organ Preservation Solutions, Pancreas, Pancreas Transplantation, Potassium Chloride, Procaine, Prospective Studies, Raffinose, Retrospective Studies, Tissue Donors