The efficacy and safety of hepatic arterial infusion of oxaliplatin plus intravenous irinotecan, leucovorin and fluorouracil in colorectal cancer with inoperable hepatic metastasis.

Simona R Volovat, Constantin Volovat, Serban M Negru, Mihai Danciu, Viorel Scripcariu

Journal: Journal of chemotherapy (Florence, Italy) 2017;28(3):235-41

PMID: 26018108

Abstract

Hepatic arterial infusion (HAI) was evaluated for different drugs to treat hepatic metastasis from colorectal cancer (CRC). Combination treatment with 5-fluorouracil (5-FU), leucovorin, oxaliplatin and irinotecan (FOLFOXIRI) is effective for CRC. A phase II study was conducted to evaluate concomitant HAI administration of oxaliplatin and intravenous leucovorin, 5-FU and irinotecan (FOLFIRI) for patients with inoperable liver metastasis, which had chemotherapy with oxaliplatin (OX) 85 mg/m(2) HAI plus systemic intravenous chemotherapy [leucovorin 200 mg/m(2), 5-FU 2400 mg/m(2) and irinotecan (IRI) 160 mg/m(2) in 48 hours]. We treated 24 patients. Neutropaenia was the most frequent toxicity. The main HAI-related toxicity was pain. Two patients (8%) obtained complete response and 17 patients (70%) partial response, giving an objective response rate of 78%. Median follow-up was 22.8 months, and median overall and disease-free survival times were 29 and 20 months, respectively. Therefore, OX HAI and intravenous FOLFIRI is feasible and effective in patients with metastatic CRC.

Address: a Regional Institute of Oncology , University of Medicine and Pharmacy 'Gr.T.Popa' , Iasi , Romania.; b Center of Oncology Euroclinic , Iasi , Romania.; c University of Medicine and Pharmacy Timisoara , Romania.; d University Hospital 'St. Spiridon' , University of Medicine and Pharmacy 'Gr.T.Popa' , Iasi , Romania.

DOI: 10.1179/1973947815Y.0000000042

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MeSH Terms: Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Colorectal Neoplasms, Disease-Free Survival, Female, Fluorouracil, Hepatic Artery, Humans, Infusions, Intra-Arterial, Infusions, Intralesional, Infusions, Intravenous, Kaplan-Meier Estimate, Leucovorin, Liver Neoplasms, Male, Middle Aged, Organoplatinum Compounds, Oxaliplatin, Treatment Outcome