Reflections on the discovery of nature's pathways to vitamin B12.

A I Scott

Journal: Chemical record (New York, N.Y.) 2002;1(3):212-27

PMID: 11895120

Abstract

The chronology of the discoveries along the pathway of vitamin B12 biosynthesis is reviewed from a personal perspective, including discussion of the most recent finding that two pathways to B12 exist--one aerobic and one anaerobic--which differ mainly in the ring contraction mechanisms which convert porphyrin to corrin.

Address: Center for Biological NMR, Chemistry Department, Texas A&M University, College Station 77843-3255, USA. [email protected]

DOI: 10.1002/tcr.1009

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MeSH Terms: Bacteria, Genes, Bacterial, Genetic Engineering, Vitamin B 12