Bacterial Stress Responses during Host Infection.

Ferric C Fang, Elaine R Frawley, Timothy Tapscott, Andrés Vázquez-Torres

Journal: Cell host & microbe 2017;20(2):133-43

PMID: 27512901

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Abstract

Pathogenic bacteria must withstand diverse host environments during infection. Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger adaptive responses within bacteria to these specific stress conditions but also direct the expression of virulence genes at an appropriate time and place. An appreciation of stress responses and their regulation is therefore essential for an understanding of bacterial pathogenesis. This review considers specific stresses in the host environment and their relevance to pathogenesis, with a particular focus on the enteric pathogen Salmonella.

Address: Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195-7735, USA; Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7735, USA. Electronic address: [email protected].; Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-7735, USA.; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

DOI: 10.1016/j.chom.2016.07.009

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MeSH Terms: Adaptation, Physiological, Gene Expression Regulation, Bacterial, Host-Pathogen Interactions, Salmonella, Salmonella Infections, Stress, Physiological, Virulence Factors