Journey toward unraveling the molecular basis of hereditary hair disorders.

Yutaka Shimomura

Journal: Journal of dermatological science 2017;84(3):232-238

PMID: 27523806

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Abstract

Recent advances in molecular genetics have led to the identification of many genes expressed in hair follicle (HF), while the precise roles of these genes in the HF have not completely been disclosed. Using the methods of forward genetics, we and others have recently identified a series of genes responsible for hereditary hair disorders in humans, including monilethrix, woolly hair, and various ectodermal dysplasia syndromes. Furthermore, expression and functional analyzes have gradually revealed that these genes are directly or indirectly related with each other. As such, the journey toward unraveling the molecular basis of hereditary hair disorders will contribute to better understanding of the complex mechanisms for HF morphogenesis and development in humans.

Address: Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan. Electronic address: [email protected].

DOI: 10.1016/j.jdermsci.2016.08.006

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MeSH Terms: Amino Acid Motifs, Ectodermal Dysplasia, Hair, Hair Diseases, Hair Follicle, Humans, Hypotrichosis, Japan, Lysophospholipids, Macular Degeneration, Monilethrix, Mutation, Missense, Signal Transduction