Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension.

Alfredo Gamboa, Rocío Figueroa, Sachin Y Paranjape, Ginnie Farley, Andre Diedrich, Italo Biaggioni

Journal: Hypertension (Dallas, Tex. : 1979) 2017;68(4):1004-10

PMID: 27528067

Free Full Text on PubMed Central View on PubMed

Abstract

Impaired nitric oxide (NO) vasodilation (endothelial dysfunction) is associated with obesity and thought to be a factor in the development of hypertension. We previously found that NO synthesis inhibition had similar pressor effects in obese hypertensives compared with healthy control during autonomic blockade, suggesting that impaired NO vasodilation is secondary to sympathetic activation. We tested this hypothesis by determining the effect of autonomic blockade (trimethaphan 4 mg/min IV) on NO-mediated vasodilation (increase in forearm blood flow to intrabrachial acetylcholine) compared with endothelial-independent vasodilation (intrabrachial sodium nitroprusside) in obese hypertensive subjects (30

Address: From the Division of Clinical Pharmacology (A.G., R.F., S.Y.P., G.F., A.D., I.B.), Departments of Medicine (A.G., R.F., S.Y.P., G.F., A.D., I.B.), and Pharmacology (I.B.), Vanderbilt University, Nashville, TN. [email protected].; From the Division of Clinical Pharmacology (A.G., R.F., S.Y.P., G.F., A.D., I.B.), Departments of Medicine (A.G., R.F., S.Y.P., G.F., A.D., I.B.), and Pharmacology (I.B.), Vanderbilt University, Nashville, TN.

DOI: 10.1161/HYPERTENSIONAHA.116.07681

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/obesity.html

Other Literature Sources:

https://scite.ai/reports/27528067

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

Subscription / membership required

Full Text Sources:

MeSH Terms: Autonomic Nerve Block, Blood Pressure Determination, Body Mass Index, Comorbidity, Cross-Over Studies, Disease Progression, Endothelium, Vascular, Female, Follow-Up Studies, Humans, Hypertension, Male, Middle Aged, Nitric Oxide, Nitroprusside, Obesity, Risk Assessment, Severity of Illness Index