Contraception: Search for an Ideal Unisex Mechanism by Targeting Ion Channels.

Polina V Lishko

Journal: Trends in biochemical sciences 2017;41(10):816-818

PMID: 27545067

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Abstract

Targeting sperm ion channels and other sperm-specific proteins is an effective way to develop unisex contraceptives, as they should have decreased side effects. This Science & Society summarizes the current advances in human sperm physiology in attempts to evaluate what would be appropriate targets for unisex contraceptives.

Address: Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: [email protected].

DOI: 10.1016/j.tibs.2016.08.002

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MeSH Terms: Calcium, Calcium Channels, Contraception, Contraceptive Agents, Male, Fertilization, Gene Expression, Humans, Large-Conductance Calcium-Activated Potassium Channel alpha Subunits, Male, Ovum, Sodium-Potassium-Exchanging ATPase, Sperm Capacitation, Sperm Motility, Spermatozoa