A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.

Address: ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain [email protected].; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Pompeu Fabra University (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.; Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.; ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Pompeu Fabra University (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Division of Metabolic Diseases and Nutritional Medicine, Munich, Germany.; Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, València, Spain.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands.; Leiden University College, The Hague, The Netherlands.; The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands.; Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands.; MRC/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; School of Social and Community Medicine, University of Bristol, Bristol, UK.; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Genetics and Bioinformatics, Area of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway.; Department of Pediatrics, Erasmus MC, Rotterdam, The Netherlands.; Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital of Munich (LMU), Munich, Germany.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Pompeu Fabra University (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.; Experimental Genetics, Sidra Medical and Research Centre, Doha, Qatar.; ISGlobal, Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; Pompeu Fabra University (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.