The interplay between cell signalling and the mevalonate pathway in cancer.

Peter J Mullen, Rosemary Yu, Joseph Longo, Michael C Archer, Linda Z Penn

Journal: Nature reviews. Cancer 2017;16(11):718-731

PMID: 27562463

Full Text on Nature Publishing Group View on PubMed

Abstract

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to produce sterols and isoprenoids that are integral to tumour growth and progression. In recent years, many oncogenic signalling pathways have been shown to increase the activity and/or the expression of MVA pathway enzymes. This Review summarizes recent advances and discusses unique opportunities for immediately targeting this metabolic vulnerability in cancer with agents that have been approved for other therapeutic uses, such as the statin family of drugs, to improve outcomes for cancer patients.

Address: Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5G 1L7.; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5G 1L7.; Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2.

DOI: 10.1038/nrc.2016.76

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https://doi.org/10.1038/nrc.2016.76

MeSH Terms: Humans, Metabolic Networks and Pathways, Mevalonic Acid, Neoplasms, Signal Transduction