Skin steroidogenesis in health and disease.

Georgios Nikolakis, Constantine A Stratakis, Theodora Kanaki, Andrej Slominski, Christos C Zouboulis

Journal: Reviews in endocrine & metabolic disorders 2017;17(3):247-258

PMID: 27761789

Abstract

The skin is an important extra-gonadal steroidogenic organ, capable of metabolizing various hormones from their precursors, as well as of synthesizing de novo a broad palette of sex steroids and glucocorticoids from cholesterol. In this manuscript, we review the major steroidogenic properties of human skin and we suggest steroidogenesis' impairment as a cardinal factor for various pathological conditions such as acne, rosacea, atopic dermatitis, and androgenic alopecia.

Address: Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany. [email protected].; Section on Endocrinology and Genetics, NICHD, NIH, Bethesda, MD, USA.; Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Auenweg 38, 06847, Dessau, Germany.; Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA.

DOI: 10.1007/s11154-016-9390-z

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https://doi.org/10.1007/s11154-016-9390-z

MeSH Terms: Humans, Nutritional Physiological Phenomena, Skin Diseases, Skin Physiological Phenomena, Steroids