Cell motility: proline-rich proteins promote protrusions.

M R Holt, A Koffer

Journal: Trends in cell biology 2001;11(1):38-46

PMID: 11146297

Full Text on Elsevier Science View on PubMed

Abstract

Many proline-rich proteins participate in delivering actin monomers to specific cellular locations where actin-rich membrane protrusions, such as ruffles, filopodia and microspikes, are formed. These protrusions are necessary for cell motility. Actin monomer is usually delivered to the site of polymerization in the form of profilactin - a complex of G-actin with a polyproline-binding protein, profilin. Here, we describe proline-rich proteins involved in regulating actin polymerization and classify them according to their role in recruiting profilin to the membrane.

Address: Department of Physiology, University College London, 21 University Street, WC1E 6JJ., London, UK.

DOI: 10.1016/s0962-8924(00)01876-6

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MeSH Terms: Actins, Amino Acid Motifs, Cell Movement, Contractile Proteins, Microfilament Proteins, Peptides, Profilins, Proline, Proline-Rich Protein Domains, Proteins, rho GTP-Binding Proteins