Sensitization of K562 Leukemia Cells to Doxorubicin by the Viscum album Extract.

Tatjana Srdic-Rajic, Nevena Tisma-Miletic, Milena Cavic, Ksenija Kanjer, Katarina Savikin, Danijel Galun, Aleksandra Konic-Ristic, Tamara Zoranovic

Journal: Phytotherapy research : PTR 2016;30(3):485-95

PMID: 26692465

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Abstract

Toxicity of conventional chemotherapeutics highlights the requirement for complementary or alternative medicines that would reduce side effects and improve their anticancer effectiveness. European mistletoe (Viscum album) has long been used as a complementary and alternative medicine supporting cancer therapy. The aim of this study was to investigate synergistic antitumor action of V. album extract and doxorubicin during co-treatment of chemoresistant chronic myelogenic leukemia K562 cells. Combined treatment of leukemia cells led to inhibitory synergism at sub-apoptotic doxorubicin concentrations and multifold reduction of cytotoxic effects in healthy control cells. Prolonged co-treatment was associated with reduced G2/M accumulation and increased expression of early and late apoptotic markers. Our data indicate that V. album extract increases antileukemic effectiveness of doxorubicin against resistant K562 cells by preventing G2/M arrest and inducing apoptosis.

Address: Department of Experimental Pharmacology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.; Institute for Medicinal Plant Research 'Dr Josif Pančić', Belgrade, Serbia.; University Clinic for Digestive Surgery, Clinical center Serbia, Belgrade, Serbia.; Belgrade University Medical School, Belgrade, Serbia.; Institute for Medical Research, Center of Research Excellence in Nutrition and Metabolism, Belgrade University, Belgrade, Serbia.; Department of Experimental Pharmacology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.; Max Plank Institute for Infection Biology, Berlin, Germany.

DOI: 10.1002/ptr.5554

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MeSH Terms: Antineoplastic Agents, Phytogenic, Apoptosis, Doxorubicin, Drug Synergism, Herb-Drug Interactions, Humans, K562 Cells, Leukemia, Phytotherapy, Plant Extracts, Viscum album