LncRNA MIAT: Myocardial infarction associated and more.

Jiangquan Liao, Qingyong He, Min Li, Yinfeng Chen, Yongmei Liu, Jie Wang

Journal: Gene 2016;578(2):158-61

PMID: 26707210

Full Text on Elsevier Science View on PubMed

Abstract

Non-coding RNAs are emerging as regulatory RNAs that participate in the regulation of gene expression and play vital roles in various biological and pathological processes. Long non-coding (lncRNA) is a novel class of non-coding RNAs that regulates gene expression by binding to chromatin regulators and interfering RNAs to affect cellular response. Myocardial infarction associated transcript (MIAT) is identified as lncRNAs, which is involved in various diseases, pathological and physiological processes, such as myocardial infarction, diabetic retinopathy, paranoid schizophrenia, microvascular dysfunction and formation of nuclear bodies, and neurogenic commitment. Here we review the growing understanding and potential utilization of MIAT.

Address: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5 Beixiange Street, Xicheng District, Beijing 100053, China; Graduate School, Beijing University of Chinese Medicine, No.11 Beisanhuan East Road, Chaoyang District, Beijing 100029, China.; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5 Beixiange Street, Xicheng District, Beijing 100053, China.; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5 Beixiange Street, Xicheng District, Beijing 100053, China. Electronic address: [email protected].; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No.5 Beixiange Street, Xicheng District, Beijing 100053, China. Electronic address: [email protected].

DOI: 10.1016/j.gene.2015.12.032

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MeSH Terms: Chromatin, Diabetic Retinopathy, Gene Expression Regulation, Humans, Myocardial Infarction, RNA Interference, RNA, Long Noncoding, Schizophrenia, Paranoid