Warfarin and Vascular Calcification.

Timothy J Poterucha, Samuel Z Goldhaber

Journal: The American journal of medicine 2017;129(6):635.e1-4

PMID: 26714212

Full Text on Elsevier Science View on PubMed

Abstract

The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP). MGP is a vitamin K-dependent protein that ordinarily prevents systemic calcification by scavenging calcium phosphate in the tissues. Warfarin-induced systemic calcification can result in adverse clinical effects. In this review article, we highlight some of the key translational and clinical studies that associate warfarin with vascular calcification.

Address: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.; Vascular Medicine Section, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: [email protected].

DOI: 10.1016/j.amjmed.2015.11.032

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MeSH Terms: Anticoagulants, Bone Density, Calcium-Binding Proteins, Extracellular Matrix Proteins, Female, Humans, Male, Mammography, Vascular Calcification, Vitamin K, Warfarin, Matrix Gla Protein