Transport mechanism of a glutamate transporter homologue GltPh.

Yurui Ji, Vincent L G Postis, Yingying Wang, Mark Bartlam, Adrian Goldman

Journal: Biochemical Society transactions 2017;44(3):898-904

PMID: 27284058

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Abstract

Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.

Address: College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, U.K.; Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, U.K. Biomedicine Research Group, Faculty of Health and Social Sciences, Leeds Beckett University, Leeds, LS1 3JT, U.K.; College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China.; Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, U.K. College of Life Sciences, Nankai University, Tianjin 300071, China [email protected] [email protected].; Astbury Centre for Structural Molecular Biology, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, U.K. College of Life Sciences, Nankai University, Tianjin 300071, China Division of Biochemistry, Department of Biosciences, University of Helsinki, Helsinki, FIN-00014, Finland [email protected] [email protected].

DOI: 10.1042/BST20160055

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MeSH Terms: Amino Acid Transport System X-AG, Aspartic Acid, Biological Transport, Protein Conformation, Pyrococcus horikoshii, Substrate Specificity