Antimycin-type depsipeptides: discovery, biosynthesis, chemical synthesis, and bioactivities.

Joyce Liu, Xuejun Zhu, Seong Jong Kim, Wenjun Zhang

Journal: Natural product reports 2017;33(10):1146-65

PMID: 27307039

Full Text on Royal Society of Chemistry View on PubMed

Abstract

Covering: up to 2016Antimycin-type depsipeptides are a family of natural products with great structural diversity and outstanding biological activities. These compounds have typically been isolated from actinomycetes and are generated from hybrid nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) assembly lines. This review covers the literature on the four classes of antimycin-type depsipeptides, which differ by macrolactone ring size, and it discusses the discovery, biosynthesis, chemical synthesis, and biological activities of this family of compounds.

Address: Department of Bioengineering, University of California, Berkeley, California, USA.

DOI: 10.1039/c6np00004e