GOLPH3 and oncogenesis: What is the molecular link?

Riccardo Rizzo, Seetharaman Parashuraman, Giovanni D'Angelo, Alberto Luini

Journal: Tissue & cell 2017;49(2 Pt A):170-174

PMID: 27378035

Full Text on Elsevier Science View on PubMed

Abstract

The Golgi phosphoprotein 3 (GOLPH3) is encoded by a gene that is located in a region of the human genome that is often amplified in different solid tumours. GOLPH3, an evolutionary conserved phosphatidylinositol 4-phosphate (PI4P) binding protein, is mainly localised at trans Golgi network (TGN). It regulates several cellular functions like Golgi vesicular trafficking, Golgi glycosylation and mitochondrial cardiolipin production. Recently, GOLPH3 was discovered to be part of the DNA damage response signalling pathway, with a role in cell survival following DNA damage. In this review, we will explore the cellular functions regulated by GOLPH3 and discuss if and how they contribute to the oncogenic activity of this intriguing Golgi localized oncoprotein.

Address: Institute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy. Electronic address: [email protected].; Institute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy.; Institute of Protein Biochemistry, National Research Council, Via P. Castellino 111, 80131 Naples, Italy; Istituto di Ricovero e Cura a Carattere Scientifico SDN, Via Emanuele Gianturco, 113, 80143 Naples, Italy. Electronic address: [email protected].

DOI: 10.1016/j.tice.2016.06.008

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MeSH Terms: Amino Acid Sequence, Carcinogenesis, Cell Transformation, Neoplastic, DNA Damage, Golgi Apparatus, Humans, Membrane Proteins, Phosphatidylinositol Phosphates, Protein Transport, trans-Golgi Network