Koch's postulates, microbial dysbiosis and inflammatory bowel disease.

V P Singh, S D Proctor, B P Willing

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2017;22(7):594-9

PMID: 27179648

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Abstract

Over the past 20 years, a growing amount of evidence supports the role of microbes and an imbalanced microbiota in inflammatory bowel disease (IBD). While many reviews have been written on the microbiota in IBD, few have considered how they fulfil the Koch's postulates. In this review, we consider how the Koch's postulates might be modified so that they can be fulfilled for polymicrobial diseases, and we discuss the progress made to date in fulfilling them.

Address: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada; Metabolic and Cardiovascular Diseases Laboratory, Alberta Institute of Human Nutrition, University of Alberta, Edmonton, Canada.; Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Canada. Electronic address: [email protected].

DOI: 10.1016/j.cmi.2016.04.018

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MeSH Terms: Causality, Coinfection, Dysbiosis, Humans, Inflammatory Bowel Diseases, Microbiological Techniques, Microbiology