The Intrinsic Fragility of DNA (Nobel Lecture).

Tomas Lindahl

Journal: Angewandte Chemie (International ed. in English) 2018;55(30):8528-34

PMID: 27220039

Abstract

Our cells contain common molecules, such as water or oxygen, that can damage DNA. In his studies Tomas Lindahl has shown how specific repair enzymes remove and replace damaged parts of DNA in a process of vital importance.

Address: Cancer Research UK, Clare Hall Laboratories, Hertfordshire, EN6 3LD, UK. [email protected].

DOI: 10.1002/anie.201602159

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MeSH Terms: Alkylating Agents, DNA, DNA Damage, DNA Glycosylases, DNA Methylation, DNA Repair, S-Adenosylmethionine