Thyroid Cancer in Pediatrics.

Josef Machac

Journal: Endocrinology and metabolism clinics of North America 2018;45(2):359-404

PMID: 27241970

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Abstract

Well differentiated thyroid cancer (DTC) in children is characterized by a high rate of response to treatment and low disease-specific mortality. Treatment of children with DTC has evolved toward a greater reliance on evaluation and monitoring with serial serum thyroglobulin measurements and ultrasound examinations. Radioiodine therapy is recommended for thyroid remnant ablation in high-risk patients, treatment of demonstrated radioiodine-avid local-regional disease not amenable to surgical resection, or distant radioiodine-avid metastatic disease. Sufficient time should be given for benefits of radioiodine therapy to be realized, with follow-up monitoring. Re-treatment with radioiodine can be deferred until progression of significant disease manifests.

Address: Nuclear Medicine, Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai, Box 1141, 1 Gustave Levy Place, New York, NY 10029, USA. Electronic address: [email protected].

DOI: 10.1016/j.ecl.2016.02.002

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MeSH Terms: Child, Humans, Iodine Radioisotopes, Pediatrics, Thyroid Function Tests, Thyroid Neoplasms