In vitro models for assessing therapeutic angiogenesis.

Clara Sanz-Nogués, Timothy O'Brien

Journal: Drug discovery today 2018;21(9):1495-1503

PMID: 27262402

Full Text on Elsevier Science View on PubMed

Abstract

Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product.

Address: Regenerative Medicine Institute (REMEDI), Biomedical Sciences Building, National University of Ireland Galway, Newcastle Road, Galway, Ireland.; Regenerative Medicine Institute (REMEDI), Biomedical Sciences Building, National University of Ireland Galway, Newcastle Road, Galway, Ireland. Electronic address: [email protected].

DOI: 10.1016/j.drudis.2016.05.016

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MeSH Terms: Cell- and Tissue-Based Therapy, Humans, Models, Biological, Neovascularization, Physiologic, Vascular Diseases