Organic Cation Transporter-Mediated Clearance of Cardiovascular Drugs: A Pharmacological Perspective.

Omar T Hassan, Reem T Hassan, Rohit R Arora

Journal: American journal of therapeutics 2017;23(3):e855-61

PMID: 25259955

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

There exist a number of mechanisms to clear xenobiotics from human circulation. For cationic drugs, clearance is performed by human organic cation transporters 1 and 2 (hOCT1 and hOCT2), which are expressed in the liver and kidney, respectively. Given the prevalence of patients taking cardiovascular drugs, the present review focuses on the elimination of circulating cardiovascular drugs by organic cation transporters (OCTs). A significant number of cardiovascular drugs compete for transport by OCT1 or OCT2, introducing the potential to alter the pharmacokinetic profile of other concomitantly administered medications. The OCT system thereby represents an important site of drug-drug interactions.

Address: 1Chicago Medical School, North Chicago, IL; and 2College of Pharmacy, North Chicago, IL.

DOI: 10.1097/MJT.0000000000000148

Link outs

Free resources

Other Literature Sources:

https://scite.ai/reports/25259955

Subscription / membership required

Full Text Sources:

http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linko...

MeSH Terms: Adrenergic beta-1 Receptor Antagonists, Anti-Arrhythmia Agents, Benzazepines, Calcium Channel Blockers, Cardiotonic Agents, Humans, Ivabradine, Organic Cation Transport Proteins, Organic Cation Transporter 1, Organic Cation Transporter 2, Potassium Channel Blockers, Ranolazine, Sodium Channel Blockers