PICALM rs3851179 Variant Confers Susceptibility to Alzheimer's Disease in Chinese Population.

Guiyou Liu, Yining Xu, Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Qinghua Jiang

Journal: Molecular neurobiology 2018;54(5):3131-3136

PMID: 27048444

Abstract

The association between PICALM rs3851179 variant and Alzheimer's disease (AD) has been well established by previous genome-wide association studies (GWAS) and candidate gene studies in European population. Recent studies investigated the association between PICALM rs3851179 and AD susceptibility in Chinese population. However, these studies reported consistent and inconsistent results. Here, we selected 9435 samples including 3704 AD cases and 5731 controls from previous studies and evaluated this association using a meta-analysis method for additive model. We did not observe significant genetic heterogeneity in Chinese population. Our results indicate significant association between PICALM rs3851179 and AD in Chinese population. The sensitivity analysis indicates that the association between rs3851179 and AD did not vary substantially. The regression analysis suggests no significant publication bias. In summary, this updated meta-analysis highlights the involvement of PICALM rs3851179 variant in Alzheimer's disease susceptibility in Chinese population.

Address: School of Life Science and Technology, Harbin Institute of Technology, Room 415, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China.; School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.; Department of Statistics, Rice University, Houston, TX, USA.; Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.; School of Life Science and Technology, Harbin Institute of Technology, Room 415, Building 2E, Science Park, Yikuang Street, Nangang District, Harbin, 150080, China. [email protected].

DOI: 10.1007/s12035-016-9886-2

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https://dx.doi.org/10.1007/s12035-016-9886-2

MeSH Terms: Alzheimer Disease, Asian People, Genetic Predisposition to Disease, Humans, Monomeric Clathrin Assembly Proteins, Polymorphism, Single Nucleotide, Publication Bias