Hydrogen sulphide in cardiovascular system: A cascade from interaction between sulphur atoms and signalling molecules.

Ming-Jie Wang, Wen-Jie Cai, Yi-Chun Zhu

Journal: Life sciences 2017;153():188-97

PMID: 27071836

Abstract

As a gasotransmitter, hydrogen sulphide exerts its extensive physiological and pathophysiological effects in mammals. The interaction between sulphur atoms and signalling molecules forms a cascade that modulates cellular functions and homeostasis. In this review, we focus on the signalling mechanism underlying the effect of hydrogen sulphide in the cardiovascular system and metabolism as well as the biological relevance to human diseases.

Copyright © 2016 Elsevier Inc. All rights reserved.

Address: Research Center on Aging and Medicine, Fudan University, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China.; Department of Basic Medicine, College of Medical Instruments and Foodstuff, University of Shanghai for Science and Technology, Shanghai, China.; Research Center on Aging and Medicine, Fudan University, Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: [email protected].
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