Bronchoprotection and bronchorelaxation in asthma: New targets, and new ways to target the old ones.

Tonio Pera, Raymond B Penn

Journal: Pharmacology & therapeutics 2017;164():82-96

PMID: 27113408

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Abstract

Despite over 50years of inhaled beta-agonists and corticosteroids as the default management or rescue drugs for asthma, recent research suggests that new therapeutic options are likely to emerge. This belief stems from both an improved understanding of what causes and regulates airway smooth muscle (ASM) contraction, and the identification of new targets whose inhibition or activation can relax ASM. In this review we discuss the recent findings that provide new insight into ASM contractile regulation, a revolution in pharmacology that identifies new ways to "tune" G protein-coupled receptors to improve therapeutic efficacy, and the discovery of several novel targets/approaches capable of effecting bronchoprotection or bronchodilation.

Address: Center for Translational Medicine and Jane and Leonard Korman Lung Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address: [email protected].; Center for Translational Medicine and Jane and Leonard Korman Lung Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address: [email protected].

DOI: 10.1016/j.pharmthera.2016.04.002

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MeSH Terms: Adrenal Cortex Hormones, Adrenergic beta-2 Receptor Agonists, Asthma, Bronchodilator Agents, Chloride Channels, Humans, Inflammation, Muscle Contraction, Muscle, Smooth, Phosphodiesterase Inhibitors, Receptor, PAR-2, Receptors, Calcium-Sensing, Receptors, G-Protein-Coupled, Receptors, GABA, Receptors, Leukotriene, Receptors, Prostaglandin E, Respiratory System, Signal Transduction, rho-Associated Kinases