Getting into the brain: Potential of nanotechnology in the management of NeuroAIDS.

Madhavan Nair, Rahul Dev Jayant, Ajeet Kaushik, Vidya Sagar

Journal: Advanced drug delivery reviews 2018;103():202-217

PMID: 26944096

Free Full Text on PubMed Central View on PubMed

Abstract

In spite of significant advances in antiretroviral (ARV) therapy, the elimination of human immunodeficiency virus (HIV) reservoirs from the periphery and the central nervous system (CNS) remains a formidable task. The incapability of ARV to go across the blood-brain barrier (BBB) after systemic administration makes the brain one of the dominant HIV reservoirs. Thus, screening, monitoring, and elimination of HIV reservoirs from the brain remain a clinically daunting and key task. The practice and investigation of nanomedicine possesses potentials for therapeutics against neuroAIDS. This review highlights the advancements in nanoscience and nanotechnology to design and develop specific size therapeutic cargo for efficient navigation across BBB so as to recognize and eradicate HIV brain reservoirs. Different navigation and drug release strategies, their biocompatibility and efficacy with related challenges and future prospects are also discussed. This review would be an excellent platform to understand nano-enable multidisciplinary research to formulate efficient nanomedicine for the management of neuroAIDS.

Address: Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. Electronic address: [email protected].; Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA. Electronic address: [email protected].; Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.

DOI: 10.1016/j.addr.2016.02.008

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/hivmedicines.html

Other Literature Sources:

Subscription / membership required

Full Text Sources:

MeSH Terms: AIDS Dementia Complex, Anti-HIV Agents, Blood-Brain Barrier, Brain, HIV, Humans, Nanomedicine