Synthesis of Amaryllidaceae Constituents and Unnatural Derivatives.

Mukund Ghavre, Jordan Froese, Milan Pour, Tomas Hudlicky

Journal: Angewandte Chemie (International ed. in English) 2018;55(19):5642-91

PMID: 26969844

Abstract

This update covers the syntheses of Amaryllidaceae alkaloids since the publication of the last major review in 2008. A short summary of past syntheses and their step count is provided for the major constituents; pancratistatin, 7-deoxypancratistatin, narciclasine, lycoricidine, lycorine, and for other natural constituents, as well as for unnatural derivatives. Discussion of biological activities is provided for unnatural derivatives. Future prospects and further developments in this area are covered at the end of the review. The literature is covered to the end of August 2015.

Address: Chemistry Department and Centre for Biotechnology, Brock University, 1812 Sir Isaac Brock way, St. Catharines, ON, L2S 3A1, Canada.; Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, CZ-500 03, Hradec Králové, Czech Republic.; Chemistry Department and Centre for Biotechnology, Brock University, 1812 Sir Isaac Brock way, St. Catharines, ON, L2S 3A1, Canada. [email protected].

DOI: 10.1002/anie.201508227

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https://doi.org/10.1002/anie.201508227

MeSH Terms: Alkaloids, Amaryllidaceae, Amaryllidaceae Alkaloids, Antineoplastic Agents, Phytogenic, Isoquinolines, Phenanthridines, Stereoisomerism, Structure-Activity Relationship