Effective microorganism - X attenuates circulating superoxide dismutase following an acute bout of intermittent running in hot, humid conditions.

Lee Taylor, Ben J Lee, Oliver R Gibson, Adrian W Midgley, Peter Watt, Alexis Mauger, Paul Castle

Journal: Research in sports medicine (Print) 2017;24(2):130-44

PMID: 27031165

Abstract

This study determined the effectiveness of antioxidant supplementation on high-intensity exercise-heat stress. Six males completed a high-intensity running protocol twice in temperate conditions (TEMP; 20.4°C), and twice in hot conditions (HOT; 34.7°C). Trials were completed following7 days supplementation with 70 ml·day(-1) effective microorganism-X (EM-X; TEMPEMX or HOTEMX) or placebo (TEMPPLA or HOTPLA). Plasma extracellular Hsp72 (eHsp72) and superoxide dismutase (SOD) were measured by ELISA. eHsp72 and SOD increased pre-post exercise (p < 0.001), with greater eHsp72 (p < 0.001) increases observed in HOT (+1.5 ng·ml(-1)) compared to TEMP (+0.8 ng·ml(-1)). EM-X did not influence eHsp72 (p > 0.05). Greater (p < 0.001) SOD increases were observed in HOT (+0.22 U·ml(-1)) versus TEMP (+0.10 U·ml(-1)) with SOD reduced in HOTEMX versus HOTPLA (p = 0.001). Physiological and perceptual responses were all greater (p < 0.001) in HOT versus TEMP conditions, with no difference followed EM-X (p > 0.05). EM-X supplementation attenuated the SOD increases following HOT, potentiating its application as an ergogenic aid to ameliorate oxidative stress.

Address: a Applied Sport and Exercise Physiology (ASEP) Research Group, Institute of Sport and Physical Activity Research (ISPAR), Department of Sport and Exercise Sciences , University of Bedfordshire , Bedford , UK.; g ASPETAR, Qatar Orthopaedic and Sports Medicine Hospital , Athlete Health and Performance Research Centre , Doha , Qatar.; b Department of Biomolecular and Sport Sciences , University of Coventry , Coventry , UK.; h Department for Health , University of Bath , Claverton Down , Bath , UK.; c Centre for Sport and Exercise Science and Medicine (SESAME) , University of Brighton, Welkin Human Performance Laboratories , Denton Road, Eastbourne , UK.; i Centre for Sports Medicine and Human Performance (CSMHP) , Brunel University London , Uxbridge , UK.; d Sport and Physical Activity Department , Edge Hill University , Ormskirk , United Kingdom.; e Endurance Research Group, School of Sport and Exercise Sciences , University of Kent , Chatham Maritime , UK.; f Muscle Cellular and Molecular Physiology (MCMP) & Applied Sport and Exercise Science(ASEP) Research Groups, Institute of Sport and Physical Activity Research (ISPAR), Department of Sport and Exercise Sciences , University of Bedfordshire , Bedford , UK.

DOI: 10.1080/15438627.2015.1126279

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MeSH Terms: Antioxidants, Biomarkers, Cross-Over Studies, Dietary Supplements, Double-Blind Method, HSP72 Heat-Shock Proteins, Heat-Shock Response, Hot Temperature, Humans, Humidity, Linear Models, Male, Oxidative Stress, Running, Superoxide Dismutase, Young Adult