Histone variants and histone modifications: a structural perspective.

J Ausió, D W Abbott, X Wang, S C Moore

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 2002;79(6):693-708

PMID: 11800010

Abstract

In this review, we briefly analyze the current state of knowledge on histone variants and their posttranslational modifications. We place special emphasis on the description of the structural component(s) defining and determining their functional role. The information available indicates that this histone "variability" may operate at different levels: short-range "local" or long-range "global", with different functional implications. Recent work on this topic emphasizes an earlier notion that suggests that, in many instances, the functional response to histone variability is possibly the result of a synergistic structural effect.

Address: Department of Biochemistry and Microbiology, University of Victoria, BC, Canada. [email protected]

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MeSH Terms: Acetylation, Amino Acid Sequence, Autoantigens, Centromere Protein A, Chromatin, Chromosomal Proteins, Non-Histone, Genetic Variation, Histones, Molecular Sequence Data, Phosphorylation, Poly Adenosine Diphosphate Ribose, Protein Conformation, Protein Processing, Post-Translational, Proteins, Ubiquitins