Bilirubin-Induced Neurotoxicity in the Preterm Neonate.

Jon F Watchko

Journal: Clinics in perinatology 2017;43(2):297-311

PMID: 27235209

Full Text on Elsevier Science View on PubMed

Abstract

Bilirubin-induced neurotoxicity in preterm neonates remains a clinical concern. Multiple cellular and molecular cascades likely underlie bilirubin-induced neuronal injury, including plasma membrane perturbations, excitotoxicity, neuroinflammation, oxidative stress, and cell cycle arrest. Preterm newborns are particularly vulnerable secondary to central nervous system immaturity and concurrent adverse clinical conditions that may potentiate bilirubin toxicity. Acute bilirubin encephalopathy in preterm neonates may be subtle and manifest primarily as recurrent symptomatic apneic events. Low-bilirubin kernicterus continues to be reported in preterm neonates, and although multifactorial in nature, is often associated with marked hypoalbuminemia.

Address: Division of Newborn Medicine, Department of Pediatrics, Magee-Womens Hospital, Children's Hospital of Pittsburgh, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, PA 15213, USA. Electronic address: [email protected].

DOI: 10.1016/j.clp.2016.01.007

Link outs

Free resources

Medical:

https://clinicaltrials.gov/search?term=AREA%5BRefe...

Other Literature Sources:

https://scite.ai/reports/27235209

Subscription / membership required

Full Text Sources:

MeSH Terms: Apnea, Apoptosis, Bilirubin, Brain, Calcium, Cell Cycle, Cell Cycle Checkpoints, Cell Membrane, Diffusion Magnetic Resonance Imaging, Endoplasmic Reticulum Stress, Humans, Hyperbilirubinemia, Neonatal, Infant, Newborn, Infant, Premature, Inflammation, Kernicterus, Magnetic Resonance Imaging, Mitochondria, Necrosis, Neurons, Oxidative Stress, Respiratory Insufficiency