Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2.

Address: Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada. [email protected].; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. [email protected].; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. [email protected].; Peter MacCallum Cancer Institute, East Melbourne, Australia. [email protected].; Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [email protected].; Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia. [email protected].; Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. [email protected].; Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Australia. [email protected].; Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia. [email protected].; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [email protected].; University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [email protected].; UPMC Cancer Center, Pittsburgh, PA, USA. [email protected].; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA. [email protected].; Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA. [email protected].; Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA. [email protected].; Department of Medicine and Genetics, University of California, San Francisco, San Francisco, CA, USA. [email protected].; Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL, USA. [email protected].; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. [email protected].; Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. [email protected].; University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. [email protected].; Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy. [email protected].; Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy. [email protected].; Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. [email protected].; Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark. [email protected].; Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark. [email protected].; Department of Clinical Genetics, Aarhus University Hospital, Aarhus N, Denmark. [email protected].; Department of Molecular Virology, Immunology and Medical Genetics, College of Medicine, The Ohio State University, Columbus, OH, USA. [email protected].; Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. [email protected].; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. [email protected].; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. [email protected].; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. [email protected].; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. [email protected].; Center for Medical Genetics, North Shore University Health System, Evanston, IL, USA. [email protected].; N.N. Petrov Institute of Oncology, St. Petersburg, Russia. [email protected].; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. [email protected].; Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. [email protected].; Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. [email protected].; Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. [email protected].; Department of Urology, Medical University of Vienna, Vienna, Austria. [email protected].; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. [email protected].; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. [email protected].; Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. [email protected].; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. [email protected].; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. [email protected].; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. [email protected].; Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk University, Brno, Czech Republic. [email protected].; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. [email protected].; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. [email protected].; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. [email protected].; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. [email protected].; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. [email protected].; Department of Oncology, Mayo Clinic, Rochester, MN, USA. [email protected].; Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, KS, USA. [email protected].; Department of Surgery, Daerim St. Mary's Hospital, Seoul, Korea. [email protected].; Department of Genetics, Portuguese Institute of Oncology, Porto, Portugal. [email protected].; Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. [email protected].; Department of Genetics, Portuguese Institute of Oncology, Porto, Portugal. [email protected].; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS (Scientific Institute of Hospitalization and Care), Padua, Italy. [email protected].; Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS (Scientific Institute of Hospitalization and Care), Padua, Italy. [email protected].; Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. [email protected].; Department of Oncology, Landspitali University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland. [email protected].; Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. [email protected].; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. [email protected].; Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. [email protected].; Genetic Counseling Unit, Hereditary Cancer Program, Biomedical Research Institute of Girona (IDIBGI), Catalan Institute of Oncology, Girona, Spain. [email protected].; Breast Cancer and Systems Biology Unit, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology, Barcelona, Spain. [email protected].; Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain. [email protected].; Oncogenetics Group, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, Spain. [email protected].; Department of Pathology, National Institute of Oncology, Budapest, Hungary. [email protected].; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. [email protected].; Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. [email protected].; The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China. [email protected].; Department of Surgery, The University of Hong Kong, Hong Kong, China. [email protected].; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. [email protected].; Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. [email protected].; Department of Oncology, San Carlos Clinical Hospital Health Research Institute (IdISSC), San Carlos Clinical Hospital, Madrid, Spain. [email protected].; Molecular Oncology Laboratory, San Carlos Clinical Hospital Health Research Institute (IdISSC), San Carlos Clinical Hospital, Madrid, Spain. [email protected].; Center for Medical Genetics, Ghent University, Ghent, Belgium. [email protected].; Center for Medical Genetics, Ghent University, Ghent, Belgium. [email protected].; Center for Medical Genetics, Ghent University, Ghent, Belgium. [email protected].; Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. [email protected].; Department of Tumour Biology, Institut Curie, Paris, France. [email protected].; CNRS UMR5558, Université Lyon 1, Lyon, France. [email protected].; Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France. [email protected].; Department of Tumour Biology, Institut Curie, Paris, France. [email protected].; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [email protected].; INSERM U1052, CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Université Lyon, Lyon, France. [email protected].; Department of Tumour Biology, Institut Curie, Paris, France. [email protected].; Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany. [email protected].; Institute of Human Genetics, University of Wurzburg, Wurzburg, Germany. [email protected].; Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. [email protected].; Institute for Medical Informatics, Statistics and Epidemiology University of Leipzig, Leipzig, Germany. [email protected].; University of Dusseldorf, Dusseldorf, Germany. [email protected].; Hannover Medical School, Hannover, Germany. [email protected].; Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany. [email protected].; Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany. [email protected].; Department of Gynaecolgy and Obstetrics, University Hospital of Schleswig-Holstein, Christian-Albrechts-University of Kiel, Kiel, Germany. [email protected].; Institute of Human Genetics, Charité, Berlin, Germany. [email protected].; Institute of Human Genetics, Leipzig, Germany. [email protected].; Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. [email protected].; Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Yorkshire Regional Genetics Service, Leeds, UK. [email protected].; Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, UK. [email protected].; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK. [email protected].; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. [email protected].; Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA, USA. [email protected].; Molecular Diagnostics Laboratory, Institute of Nuclear and Radiological Sciences and Technology (INRASTES), National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece. [email protected].; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece. [email protected].; Department of Medical Science, University of Turin, Turin, Italy. [email protected].; AO Città della Salute e della Scienza, Turin, Italy. [email protected].; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. [email protected].; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. [email protected].; Section of Medical Oncology, Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy. [email protected].; Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy. [email protected].; Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. [email protected].; Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Scientific Institute of Hospitalization and Care), AOU San Martino - IST National Institute for Cancer Research, Genoa, Italy. [email protected].; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. [email protected].; Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy. [email protected].; Unit of Genetic Counselling, Medical Oncology Department, Regina Elena National Cancer Institute, Rome, Italy. [email protected].; Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), 20133, Milan, Italy. [email protected].; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), Milan, Italy. [email protected].; Unit of Medical Genetics, Department of Preventive and Predictive Medicine, IRCCS (Scientific Institute of Hospitalization and Care), National Cancer Institute (INT), Milan, Italy. [email protected].; Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), Milan, Italy. [email protected].; Division of Cancer Prevention and Genetics, European Institute of Oncology (IEO), Milan, Italy. [email protected].; Division of Experimental Oncology, CRO Aviano National Cancer Institute, Aviano, PN, Italy. [email protected].; IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. [email protected].; Cogentech Cancer Genetic Test Laboratory, Milan, Italy. [email protected].; National Cancer Institute "Giovanni Paolo II", Bari, Italy. [email protected].; IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. [email protected].; Clinical Cancer Genetics, City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA, USA. [email protected].; Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [email protected].; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. [email protected].; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. [email protected].; Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain. [email protected].; Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia. [email protected].; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [email protected].; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [email protected].; Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. [email protected].; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. [email protected].; Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA. [email protected].; Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA. [email protected].; State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. [email protected].; Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. [email protected].; Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. [email protected].; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA. [email protected].; Department of Pathology & Molecular Medicine, Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON, Canada. [email protected].; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. [email protected].; Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA. [email protected].; Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia. [email protected].; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. [email protected].; Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena, 324, 00161, Rome, Italy. [email protected].