L-Rhamnose isomerase and its use for biotechnological production of rare sugars.

Wei Xu, Wenli Zhang, Tao Zhang, Bo Jiang, Wanmeng Mu

Journal: Applied microbiology and biotechnology 2016;100(7):2985-92

PMID: 26875877

Abstract

L-Rhamnose isomerase (L-RI, EC 5.3.1.14), catalyzing the isomerization between L-rhamnose and L-rhamnulose, plays an important role in microbial L-rhamnose metabolism and thus occurs in a wide range of microorganisms. It attracts more and more attention because of its broad substrate specificity and its great potential in enzymatic production of various rare sugars. In this article, the enzymatic properties of various reported L-RIs were compared in detail, and their applications in the production of L-rhamnulose and various rare sugars including D-allose, D-gulose, L-lyxose, L-mannose, L-talose, and L-galactose were also reviewed.

Address: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China. [email protected].; Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China. [email protected].

DOI: 10.1007/s00253-016-7369-z

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MeSH Terms: Aldose-Ketose Isomerases, Bacillus subtilis, Bacterial Proteins, Biotechnology, Escherichia coli, Galactose, Gene Expression, Glucose, Hexoses, Lactones, Mannose, Pentoses, Rhamnose, Stereoisomerism, Thermotoga maritima