Cinnamaldehydes in Cancer Chemotherapy.

Su-Hyung Hong, Ismail Ahmed Ismail, Sung-Min Kang, Dong Cho Han, Byoung-Mog Kwon

Journal: Phytotherapy research : PTR 2017;30(5):754-67

PMID: 26890810

Full Text on Ovid Technologies, Inc. View on PubMed

Abstract

Cinnamaldehyde and cinnamaldehyde-derived compounds are candidates for the development of anticancer drugs that have received extensive research attention. In this review, we summarize recent findings detailing the positive and negative aspects of cinnamaldehyde and its derivatives as potential anticancer drug candidates. Furthermore, we describe the in vivo pharmacokinetics and metabolism of cinnamaldehydes. The oxidative and antioxidative properties of cinnamaldehydes, which contribute to their potential in chemotherapy, have also been discussed. Moreover, the mechanism(s) by which cinnamaldehydes induce apoptosis in cancer cells have been explored. In addition, evidence of the regulatory effects of cinnamaldehydes on cancer cell invasion and metastasis has been described. Finally, the application of cinnamaldehydes in treating various types of cancer, including breast, prostate, and colon cancers, has been discussed in detail. The effects of cinnamaldehydes on leukemia, hepatocellular carcinoma, and oral cancer have been summarized briefly. Copyright © 2016 John Wiley & Sons, Ltd.

Address: Department of Oral Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, 700-412, Korea.; Laboratory of Molecular Cell Biology, Department of Zoology, Faculty of Science, Assiut University, Assiut, 71516, Egypt.; Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 125 Gwahakro Yoosunggu, Daejeon, 305-806, Korea.

DOI: 10.1002/ptr.5592

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MeSH Terms: Acrolein, Antineoplastic Agents, Humans, Neoplasms